Randomized Controlled Trial
Affiliations
- PMID: 25135262
Free article
Randomized Controlled Trial
Comparison of fumaric acid 5% cream versus triamcinolone 0.1% cream in the treatment of hand eczema
Farideh Jowkar et al. Acta Med Iran. 2014.
Free article
Abstract
Hand eczema is a common distressing skin problem. It is an immune reaction to haptens. Thus, substances that inhibit Immune system can be effective in the treatment of hand eczema. In this study, topical fumaric acid 5% cream is compared with topical steroid in the treatment of hand eczema. Patients with hand eczema were randomly divided into two groups. One group received fumaric acid 5% in a cream base, and the other received triamcinolone 0.1% in the same cream base. Both groups used creams twice daily for one month. Patients were checked for erythema, excoriation, population and lichenification, EASI score, and pruritus before and after treatment. In both groups, the mean of all signs of the disease and EASI score decreased after one month of treatment. There was no significant difference between the two treatments in decreasing erythema, but excoriation, population, lichenification, EASI score and itching were all decreased more in triamcinolone 0.1 % group. Although fumaric acid can inhibit the immune system; it was less effective for the treatment of all signs of hand eczema except erythema in comparison to triamcinolone. These results may be justified for two reasons: low penetration of topical fumaric acid through the skin or a low concentration used in this study.
Similar articles
The efficacy of '0.05% Clobetasol + 2.5% zinc sulphate' cream vs. '0.05% Clobetasol alone' cream in the treatment of the chronic hand eczema: a double-blind study.
Faghihi G, Iraji F, Shahingohar A, Saidat A. Faghihi G, et al. J Eur Acad Dermatol Venereol. 2008 May;22(5):531-6. doi: 10.1111/j.1468-3083.2007.02533.x. Epub 2008 Feb 12. J Eur Acad Dermatol Venereol. 2008. PMID: 18284511 Clinical Trial.
Comparison of a modified hydrocortisone/urea cream and betamethasone valerate cream in the treatment of dry eczema.
Williamson DM. Williamson DM. J Int Med Res. 1987 Mar-Apr;15(2):99-105. doi: 10.1177/030006058701500207. J Int Med Res. 1987. PMID: 3582724 Clinical Trial.
Steroid-free emollient formulations reduce symptoms of eczema and improve quality of life.
Weber TM, Babcock MJ, Herndon JH Jr, Schoelermann AM, Filbry AW, Scherdin U, Neufang G, Rippke F. Weber TM, et al. J Drugs Dermatol. 2014 May;13(5):589-95. J Drugs Dermatol. 2014. PMID: 24809884 Clinical Trial.
Patient acceptability, efficacy, and skin biophysiology of a cream and cleanser containing lipid complex with shea butter extract versus a ceramide product for eczema.
Hon KL, Tsang YC, Pong NH, Lee VW, Luk NM, Chow CM, Leung TF. Hon KL, et al. Hong Kong Med J. 2015 Oct;21(5):417-25. doi: 10.12809/hkmj144472. Epub 2015 Aug 28. Hong Kong Med J. 2015. PMID: 26314567 Review.
Spotlight on topical pimecrolimus in atopic dermatitis.
Wellington K, Jarvis B. Wellington K, et al. Am J Clin Dermatol. 2002;3(6):435-8. doi: 10.2165/00128071-200203060-00006. Am J Clin Dermatol. 2002. PMID: 12113651 Review.
Cited by
Effect of herbal cream containing Fumaria officinalis and silymarin for treatment of eczema: A randomized double-blind controlled clinical trial.
Iraji F, Sharif Makhmalzadeh B, Abedini M, Aghaei A, Siahpoush A. Iraji F, et al. Avicenna J Phytomed. 2022 Mar-Apr;12(2):155-162. doi: 10.22038/AJP.2022.19492. Avicenna J Phytomed. 2022. PMID: 35614885 Free PMC article.
Narrow-band UVB combined with compound clobetasol propionate can improve the therapeutic effect in hand eczema patients.
Yuan N, Chen Z, Li L. Yuan N, et al. Am J Transl Res. 2021 Jul 15;13(7):8193-8199. eCollection 2021. Am J Transl Res. 2021. PMID: 34377305 Free PMC article.
Interventions for hand eczema.
Christoffers WA, Coenraads PJ, Svensson Å, Diepgen TL, Dickinson-Blok JL, Xia J, Williams HC. Christoffers WA, et al. Cochrane Database Syst Rev. 2019 Apr 26;4(4):CD004055. doi: 10.1002/14651858.CD004055.pub2. Cochrane Database Syst Rev. 2019. PMID: 31025714 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
- Tehran University of Medical Sciences, The Center for Electronic Resources Provision & Journals Development
Medical
- Genetic Alliance
- MedlinePlus Health Information