Can type 2 diabetes cause high blood pressure

Review

Table of Contents Show

Hypertension with diabetes mellitus: physiology and pathology
Similar articles
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
What should your blood pressure be with type 2 diabetes?
Is blood pressure and blood sugar related?
Can diabetes trigger high blood pressure?
Why does type 2 diabetes cause hypertension?

. 2018 Jun;41(6):389-393.

doi: 10.1038/s41440-018-0034-4. Epub 2018 Mar 19.

Affiliations

PMID: 29556093
DOI: 10.1038/s41440-018-0034-4

Review

Hypertension with diabetes mellitus: physiology and pathology

Mitsuru Ohishi. Hypertens Res. 2018 Jun.

Abstract

Elevated blood pressure is closely related to increased circulatory fluid volume and peripheral vascular resistance. Patients with diabetes mellitus experience increased peripheral artery resistance caused by vascular remodeling and increased body fluid volume associated with insulin resistance-induced hyperinsulinemia and hyperglycemia. Both of these mechanisms elevate systemic blood pressure. Thus, fully understanding the pathophysiology of hypertension in diabetes mellitus requires knowing the natural history of type 2 diabetes. Patients exhibit hyperinsulinemia with insulin resistance due to impaired glucose tolerance and early-stage diabetes. Hypertension occurs because of increased body fluid volume. After reaching mid-stage diabetes the vascular remodeling has progressed and peripheral vascular resistance also contributes to hypertension. Moreover, vascular remodeling strongly influences diabetic complications. Specifically, afferent arteriolar remodeling during diabetic nephropathy leads to increased glomerular pressure. Thus, treatment with a renin-angiotensin system inhibitor that promotes renal damage regression is critical to lowering the systemic blood pressure and dilating efferent arterioles to reduce glomerular pressure.

Cited by

Insulin resistance based on postglucose load measure is associated with prevalence and burden of cerebral small vessel disease.
Zhou M, Wang S, Jing J, Yang Y, Cai X, Meng X, Mei L, Lin J, Li S, Li H, Wei T, Wang Y, Pan Y, Wang Y. Zhou M, et al. BMJ Open Diabetes Res Care. 2022 Oct;10(5):e002897. doi: 10.1136/bmjdrc-2022-002897. BMJ Open Diabetes Res Care. 2022. PMID: 36220196 Free PMC article.
Antihypertensive treatment improves glycemic control in patients with newly diagnosed type 2 diabetes mellitus: A prospective cohort study.
Li JC, Cheng PC, Huang CN, Jian LF, Wu YS, Lin CL. Li JC, et al. Front Endocrinol (Lausanne). 2022 Sep 9;13:935561. doi: 10.3389/fendo.2022.935561. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36157468 Free PMC article.
Effects of Piper sarmentosum Roxb. on hypertension and diabetes mellitus: A systematic review and meta-analysis.
Othman NS, Che Roos NA, Aminuddin A, Murthy JK, A Hamid A, Ugusman A. Othman NS, et al. Front Pharmacol. 2022 Aug 25;13:976247. doi: 10.3389/fphar.2022.976247. eCollection 2022. Front Pharmacol. 2022. PMID: 36091787 Free PMC article.
Time-Restricted Eating in Metabolic Syndrome-Focus on Blood Pressure Outcomes.
Duan D, Bhat S, Jun JC, Sidhaye A. Duan D, et al. Curr Hypertens Rep. 2022 Nov;24(11):485-497. doi: 10.1007/s11906-022-01219-z. Epub 2022 Sep 6. Curr Hypertens Rep. 2022. PMID: 36066740 Free PMC article. Review.
Molecular mechanisms underlying some major common risk factors of stroke.
Alkahtani R. Alkahtani R. Heliyon. 2022 Aug 18;8(8):e10218. doi: 10.1016/j.heliyon.2022.e10218. eCollection 2022 Aug. Heliyon. 2022. PMID: 36060992 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

Other Literature Sources
- scite Smart Citations
Medical
- Genetic Alliance
- MedlinePlus Consumer Health Information
- MedlinePlus Health Information

What should your blood pressure be with type 2 diabetes?

Blood pressure should be below 140/80mmHg for people with diabetes or below 130/80mmHg if you have kidney or eye disease or any condition that affects blood vessels and blood supply to the brain. But it is important to speak to your healthcare team about your individual target.

Yes. It turns out that hyperglycemia can contribute to hypertension. High blood sugar can increase blood pressure through two primary means. First, untreated hyperglycemia can lead to nerve and blood vessel damage.

Can diabetes trigger high blood pressure?

High blood pressure is twice as likely to strike a person with diabetes than a person without diabetes. Left untreated, high blood pressure can lead to heart disease and stroke.

Why does type 2 diabetes cause hypertension?

Patients with diabetes mellitus experience increased peripheral artery resistance caused by vascular remodeling and increased body fluid volume associated with insulin resistance-induced hyperinsulinemia and hyperglycemia. Both of these mechanisms elevate systemic blood pressure.